Description

[Arg3]-Amyloid β-Protein (1-40) is a synthetic peptide fragment corresponding to a specific isoform of the amyloid-beta protein. This compound is of critical importance for research into the molecular mechanisms underlying Alzheimer's disease and other amyloid-related disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers for use as a key reference standard, antigen, and substrate in biochemical assays.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, toxicity, and structure-activity relationships.
• Drug Discovery & Screening: Serving as a target substrate for high-throughput screening (HTS) assays to identify potential therapeutic inhibitors of amyloid aggregation.
• Immunoassay Development: Acting as a critical antigen for the production and calibration of antibodies used in ELISA and other immunodetection methods.
• Biomarker Research: Use as a calibrated standard in mass spectrometry and chromatographic methods for quantifying amyloid-beta variants in biological samples.
• In Vitro Model Systems: Preparation of synthetic amyloid fibrils and oligomers for cell culture studies to model disease pathology.
• Quality Control Reference: Providing a defined standard for the quality assurance of related diagnostic kits and research reagents.

Basic Information

Product Name	[Arg3]-Amyloid β-Protein (1-40)
CAS No.	1802084-01-0
Molecular Formula	C194H295N55O58S
Molecular Weight	4329.8 g/mol
Synonyms	Abeta (1-40) R3; Aβ1-40 (R3); Amyloid β-Protein (1-40) Arg3 variant; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (with R3 substitution); Synthetic Amyloid-β (1-40) Peptide; Aβ40 R3; ARG3-AMYLOID BETA PEPTIDE (1-40); Alzheimer's Disease Amyloid Peptide Fragment
EINECS	Contact for details

Quality Control

Every batch of [Arg3]-Amyloid β-Protein (1-40) is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous purity and identity verification using advanced analytical techniques to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and mass spectrometry data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. Aliquot into single-use vials to minimize freeze-thaw cycles and exposure to atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.