Description

Amyloid Dan Protein (1-34) Trifluoroacetate Salt/Amyloid Dan Protein Precursor??? (244-277) is a synthetic peptide fragment related to amyloid precursor protein (APP) processing, supplied as a trifluoroacetate salt for enhanced stability and solubility. This high-purity biochemical is critical for advanced research into neurodegenerative disease mechanisms, particularly Alzheimer's disease, and for screening potential therapeutic compounds. It is an essential tool for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neurobiology and drug discovery.

Application

• Neurodegenerative Disease Research: Used as a key reagent in studies investigating the aggregation, toxicity, and clearance mechanisms of amyloid-beta related peptides.
• Drug Discovery & Screening: Serves as a target or standard in high-throughput screening (HTS) assays to identify and validate novel inhibitors of amyloid aggregation or modulators of APP processing.
• Biochemical Assay Development: Employed as a calibrated standard for developing and validating ELISA, Western blot, or other immunoassays targeting specific APP fragments.
• Cell Culture & In Vitro Studies: Applied in cellular models to study the effects of specific APP peptides on neuronal health, signaling pathways, and inflammatory responses.
• Structural Biology: Utilized in nuclear magnetic resonance (NMR) spectroscopy or X-ray crystallography studies to determine the three-dimensional structure of APP-derived peptides.
• Antibody Production & Validation: Acts as an immunogen for generating specific antibodies or as a coating antigen for characterizing antibody specificity and affinity.

Basic Information

Product Name	Amyloid Dan Protein (1-34) Trifluoroacetate Salt/Amyloid Dan Protein Precursor??? (244-277)
CAS No.	1802082-60-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	APP (244-277) peptide; Amyloid beta A4 protein fragment (244-277); Amyloid Dan Precursor Peptide (244-277); Synthetic APP peptide; TFA salt of APP (244-277); Alzheimer's disease-related peptide; Amyloid precursor protein fragment 244-277
EINECS	Contact for details

Quality Control

Our Amyloid Dan Protein (1-34) Trifluoroacetate Salt/Amyloid Dan Protein Precursor??? (244-277) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with research-grade standards and supporting your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For optimal performance, prepare aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Trifluoroacetate Content	≤ 15.0% (by HPLC)
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.