Description

Amyloid Bri Protein (1-34) is a synthetic peptide fragment corresponding to the first 34 amino acids of the Amyloid Bri protein, a key component in Familial British Dementia (FBD). This compound is crucial for neuroscience research, serving as a fundamental tool for studying the mechanisms of amyloid deposition and neurotoxicity associated with this rare genetic disorder. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and diagnostic developers focused on neurodegenerative diseases.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structural properties, and pathogenic mechanisms of ABri amyloid peptides.
• Drug Discovery Screening: Used as a target or reference standard in high-throughput assays to identify potential inhibitors of ABri fibrillization.
• Antibody Development & Validation: Acts as a critical antigen for the production and characterization of antibodies specific to Familial British Dementia.
• Diagnostic Assay Development: Serves as a calibrator or control in the development of immunoassays (e.g., ELISA) for detecting ABri-related biomarkers.
• Cell Culture & In Vitro Models: Used to induce amyloid toxicity in neuronal cell cultures to model disease pathology and test neuroprotective compounds.
• Structural Biology Studies: Essential for NMR, X-ray crystallography, and other techniques to determine the 3D conformation of the ABri peptide.

Basic Information

Product Name	Amyloid Bri Protein (1-34)
CAS No.	1802081-65-7
Molecular Formula	C164H262N50O51S
Molecular Weight	~3773.2 g/mol
Synonyms	ABri (1-34) Peptide; Amyloid Bri Peptide Fragment 1-34; ITL-Bri Peptide; Familial British Dementia Peptide; ABri Protein Fragment; pGlu-Asn-Asn-Lys-Phe-His-Glu-Ser-Gly-Tyr-Glu-Arg-Asp-Ser-Ala-Glu-Ala-Phe-Pro-Val-Glu-Asn-Pro-Gly-Tyr-Tyr-Tyr-Arg-Leu-Ala-His-His-Ser; ITL-Bri (1-34); Synthetic ABri Amyloid Peptide
EINECS	Contact for details

Quality Control

Our Amyloid Bri Protein (1-34) is manufactured under strict quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing to ensure high purity and sequence fidelity. Certificates of Analysis (COA) are provided, detailing results for purity (HPLC), molecular weight confirmation (MS), and peptide content. We adhere to cGMP principles for peptide synthesis to ensure batch-to-batch consistency and reliability for critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder desiccated. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	3773.2 ± 2 Da
Peptide Content	≥ 80%
Solubility	Soluble in water or dilute acetic acid
Single Peak on HPLC	Pass
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.