Description

(Des-Thr5)-Glucagon CAS NO 1802078-27-8 is a synthetic peptide analog of the glucagon hormone, specifically designed with a deletion at the threonine-5 position. This modification is of significant interest for advanced research into glucagon receptor activity, metabolic pathways, and the development of novel therapeutic agents. It serves as a critical biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on diabetes, obesity, and metabolic disorders.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active ingredient in the study of glucagon receptor agonists and antagonists.
• Metabolic Disorder Studies: A key reagent for investigating the role of glucagon in glucose homeostasis, lipid metabolism, and energy balance.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays and receptor binding studies.
• Structure-Activity Relationship (SAR) Analysis: Essential for understanding how specific amino acid modifications affect peptide hormone potency and selectivity.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and safety profiles of potential anti-diabetic or weight-management therapies.
• Academic Research: Serves as a precise tool in university and institutional labs for endocrinology and peptide chemistry research.

Basic Information

Product Name	(Des-Thr5)-Glucagon
CAS No.	1802078-27-8
Molecular Formula	C152H225N43O48S
Molecular Weight	~3464.7 g/mol
Synonyms	Glucagon (5-29), human; Des-Thr5-Glucagon; Glucagon (5-29) amide; [Des-Thr5]-Glucagon; Glucagon fragment 5-29; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2 (Thr5 deleted); Glucagon analog (Des-Thr5)
EINECS	Contact for details

Quality Control

Our (Des-Thr5)-Glucagon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and related substances is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.