Description

Cys-Gly-His-Gly-Asn-Lys-Ser-Amyloid-Protein (33-40) is a synthetic peptide fragment corresponding to a specific sequence of the amyloid precursor protein, a key molecule of interest in neurological research. This high-purity reference standard is critical for advancing studies into protein aggregation mechanisms and associated biochemical pathways. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on neurodegenerative diseases, biomarker discovery, and therapeutic development.

Application

• Biomedical Research: Used as a critical reference standard in studies of amyloid β-protein structure, aggregation kinetics, and toxicity.
• Drug Discovery & Screening: Serves as a target or inhibitor in high-throughput assays to identify potential therapeutic compounds for Alzheimer's disease and related conditions.
• Diagnostic Development: Employed in the development and calibration of immunoassays (ELISA, Western Blot) for detecting amyloid-related biomarkers.
• Biophysical Studies: Essential for spectroscopic analysis (NMR, CD, FTIR) to understand peptide conformation and stability under various conditions.
• Academic & Institutional Research: Provides a well-defined substrate for fundamental research into protein misfolding and neurodegenerative disease pathology.

Basic Information

Product Name	Cys-Gly-His-Gly-Asn-Lys-Ser-Amyloid-Protein (33-40)
CAS No.	1802078-22-3
Molecular Formula	C32H52N14O12S
Molecular Weight	864.91 g/mol
Synonyms	Amyloid β-Protein (33-40); Aβ(33-40); Amyloid β-Peptide (33-40); H-Cys-Gly-His-Gly-Asn-Lys-Ser-OH; APP (672-679); CGHGNKS; Amyloid Precursor Protein Fragment (33-40)
EINECS	Contact for details

Quality Control

Every batch of Cys-Gly-His-Gly-Asn-Lys-Ser-Amyloid-Protein (33-40) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC and MS, to ensure high purity and batch-to-batch consistency essential for reproducible research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.