Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-D-Nva-Oh is a specialized, high-purity amino acid derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex peptide chains and other bioactive molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D teams, peptide synthesis specialists, and fine chemical manufacturers developing novel therapeutic agents and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected, N-methylated D-norvaline derivative, it serves as a key monomer for the controlled assembly of modified peptides, particularly where backbone N-methylation is required to enhance metabolic stability and membrane permeability.
• Peptidomimetic Drug Discovery: Used in the research and development of peptidomimetics, where its structural features help mimic natural peptides while improving drug-like properties such as oral bioavailability.
• Non-Proteinogenic Amino Acid Incorporation: Essential for introducing the non-natural D-norvaline residue into synthetic peptides and proteins, enabling the study of structure-activity relationships and the creation of novel bioactive compounds.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse chemical libraries for high-throughput screening against various biological targets.
• Protease Substrate Analog Synthesis: Employed in the synthesis of specific inhibitors and substrates for enzymatic studies, leveraging its modified amino acid structure.
• Academic and Industrial Research: Supports fundamental research in medicinal chemistry, chemical biology, and synthetic methodology development.

Basic Information

Item	Details
Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-D-Nva-Oh
CAS No.	1799443-42-7
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-N-Me-D-Nva-OH; Fmoc-N-methyl-D-norvaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-norvaline; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]pentanoic acid; Nα-Fmoc-N-methyl-D-norvaline; Fmoc-D-N-methylnorvaline; N-Fmoc-N-Me-D-Nva; Fmoc-N-Me-D-2-aminopentanoic acid
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-D-Nva-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under anhydrous conditions, such as in a desiccator or under an inert atmosphere, to prevent degradation. For long-term storage, temperatures of 2-8°C are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.