Description

Levofloxacin (S)-9,10-Difluoro-3-Methyl-2,3,5,6-Tetrahydro-7H-Pyrido[1,2,3-De]-1,4-Benzoxazin-7-One is a high-purity, synthetic fluoroquinolone antibiotic intermediate. This compound is critical for the reliable and scalable production of active pharmaceutical ingredients (APIs) in the pharmaceutical industry. It is primarily required by manufacturers of anti-infective drugs, research institutions developing new antibacterial agents, and fine chemical suppliers serving the global pharmaceutical supply chain.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral intermediate in the industrial-scale production of Levofloxacin API.
• Pharmaceutical Research & Development: Used in the discovery and process optimization of novel fluoroquinolone-based antibacterial drugs.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.
• Fine Chemical Manufacturing: A building block for synthesizing more complex, fluorinated heterocyclic compounds for specialized applications.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs and CDMOs producing generic and branded antibiotic formulations for global markets.

Basic Information

Product Name	Levofloxacin (S)-9,10-Difluoro-3-Methyl-2,3,5,6-Tetrahydro-7H-Pyrido[1,2,3-De]-1,4-Benzoxazin-7-One
CAS No.	1798902-76-7
Molecular Formula	C18H20F2N3O4
Molecular Weight	380.37 g/mol
Synonyms	(S)-(-)-Ofloxacin; Levofloxacin Intermediate; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid intermediate; (3S)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid precursor; (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid related compound; S-(-)-Ofloxacin; Levofloxacin impurity standard; (S)-Ofloxacin
EINECS	Contact for details

Quality Control

Our Levofloxacin intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral HPLC for enantiomeric excess, to ensure compliance with pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.