Description

1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(3-Methyl-1-Oxido-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a key synthetic precursor for novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and API producers focused on anti-infective drug development.

Application

• Critical intermediate in the synthesis of novel fluoroquinolone antibiotic candidates.
• Building block for pharmaceutical research targeting broad-spectrum antibacterial activity.
• Used in process development and scale-up for active pharmaceutical ingredient (API) manufacturing.
• Reference standard for analytical method development and quality control in pharmaceutical production.
• Key material in academic and industrial research exploring structure-activity relationships (SAR) of quinolone derivatives.
• Starting material for the preparation of more complex, functionally modified quinolone structures.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(3-Methyl-1-Oxido-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	1798008-43-1
Molecular Formula	C19H20FN3O5
Molecular Weight	389.38 g/mol
Synonyms	7-(3-Methyl-1-oxido-1-piperazinyl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-oxido-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gepotidacin Intermediate; GSK2140944 Intermediate; Novel Quinolone Intermediate; Antibacterial Intermediate; N-Oxide Piperazinyl Quinolone Carboxylic Acid
EINECS	Contact for details

Quality Control

Our production adheres to stringent Good Manufacturing Practice (GMP) principles suitable for pharmaceutical intermediates. Every batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.