Description

6-[[3-[4-(4-Methoxyphenyl)-1-Piperazinyl-D4]Propyl]Amino]-1,3-Dimethyl-2,4(1H,3H)-Pyrimidinedione is a deuterated derivative of a piperazinyl-pyrimidinedione compound, a sophisticated building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled internal standard, which is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). This high-purity compound is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemistry teams focused on drug metabolism and pharmacokinetics (DMPK) studies for novel therapeutics.

Application

• Internal Standard for LC-MS/MS Bioanalysis: Used as a deuterium-labeled analog to quantify the parent drug or its metabolites in biological matrices (plasma, serum, urine) with high precision.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for tracing drug absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical research.
• Pharmaceutical Reference Standard: Serves as a certified reference material for method development, validation, and quality control in analytical laboratories.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites.
• Clinical Trial Support: Enables robust and GLP-compliant bioanalytical data generation for regulatory submissions to agencies like the FDA and EMA.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy quantification techniques to minimize matrix effects and ionization variability.

Basic Information

Product Name	6-[[3-[4-(4-Methoxyphenyl)-1-Piperazinyl-D4]Propyl]Amino]-1,3-Dimethyl-2,4(1H,3H)-Pyrimidinedione
CAS No.	1794780-14-5
Molecular Formula	C20H26D4N6O3
Molecular Weight	390.52 g/mol
Synonyms	6-[[3-[4-(4-Methoxyphenyl)-1-Piperazinyl-D4]Propyl]Amino]-1,3-Dimethyluracil; Deuterated Piperazinyl-Pyrimidinedione Derivative; 1,3-Dimethyl-6-[[3-[4-(4-methoxyphenyl)-1-piperazinyl-2,2,3,3-d4]propyl]amino]-2,4(1H,3H)-pyrimidinedione; (D4)-Labeled PDE Inhibitor Intermediate; 6-((3-(4-(4-Methoxyphenyl)piperazin-1-yl-D4)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure the highest isotopic purity and chemical integrity. Each batch undergoes comprehensive analysis using advanced techniques including NMR (for deuterium incorporation verification), HPLC, and LC-MS to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results. We support research requiring compliance with GLP and cGMP guidelines for reference standard production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.