Description

3-Ethynyl-2,4-Difluoroaniline is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining an ethynyl group with a difluoro-substituted aniline. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapies. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides with enhanced efficacy.
• Material Science Research: Serves as a precursor for organic electronic materials and advanced polymers due to its conjugated ethynyl group.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalytic processes in fine chemical synthesis.
• Fluorinated Compound Library: An essential component for constructing diverse screening libraries in medicinal chemistry for drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions where applicable.

Basic Information

Product Name	3-Ethynyl-2,4-Difluoroaniline
CAS No.	1792939-17-3
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2,4-Difluoro-3-ethynylaniline; 3-Ethynyl-2,4-difluorobenzenamine; Benzenamine, 3-ethynyl-2,4-difluoro-; 3-Ethynyl-2,4-difluoro-phenylamine; 2,4-Difluoro-3-ethynylphenylamine; 3-(Ethynyl)-2,4-difluoroaniline
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-2,4-Difluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its light-sensitive nature, prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.