Description

Ticagrelor Sulphone is a key pharmaceutical intermediate and impurity standard, specifically the sulfone derivative of the antiplatelet drug Ticagrelor. This compound is critical for quality control and analytical research in the development and manufacturing of cardiovascular medications. It is primarily utilized by pharmaceutical R&D laboratories, quality assurance departments, and manufacturers of active pharmaceutical ingredients (APIs) to ensure product purity, safety, and regulatory compliance.

Application

• Primary use as a reference standard and impurity marker in the quality control of Ticagrelor API and finished dosage forms.
• Critical intermediate in pharmaceutical research and development for studying drug metabolism and degradation pathways.
• Essential for analytical method development and validation (HPLC, LC-MS) in compliance with ICH guidelines.
• Used in stability studies to identify and quantify degradation products.
• Serves as a starting material or building block for the synthesis of novel chemical entities in medicinal chemistry.
• Supports regulatory filings (e.g., for FDA, EMA) by providing necessary impurity characterization data.

Basic Information

Product Name	Ticagrelor Sulphone
CAS No.	1788033-05-5
Molecular Formula	C23H28F2N6O5S
Molecular Weight	538.57 g/mol
Synonyms	(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 1,1-Dioxide; Ticagrelor Sulfone; Ticagrelor Impurity Sulphone; AZD6140 Sulphone; AR-C126455 Sulphone; Ticagrelor Related Compound Sulphone
EINECS	Contact for details

Quality Control

Our Ticagrelor Sulphone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by spectroscopic methods (IR, NMR, MS), and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specifications and test results to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.