Description

tert-Butyl 2-(4-Amino-6-Chloropyrimidin-5-Yloxy)Ethylmethylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidine-based structure. This compound is crucial for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise chemical functionality and reliable purity are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors and other small-molecule drugs.
• Biochemical Research: Used as a standard or reagent in medicinal chemistry research for structure-activity relationship (SAR) studies.
• API Development: Serves as a key building block in the research and development (R&D) and pilot-scale production of new active pharmaceutical ingredients.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects.
• Process Chemistry: Employed in route scouting and optimization for more efficient and scalable manufacturing processes.

Basic Information

Product Name	tert-Butyl 2-(4-Amino-6-Chloropyrimidin-5-Yloxy)Ethylmethylcarbamate
CAS No.	1787294-51-2
Molecular Formula	C12H19ClN4O3
Molecular Weight	302.76 g/mol
Synonyms	tert-Butyl N-[2-[(4-Amino-6-chloropyrimidin-5-yl)oxy]ethyl]-N-methylcarbamate; 5-[(2-[[(tert-Butoxy)carbonyl](methyl)amino]ethoxy)]-6-chloropyrimidin-4-amine; 2-(4-Amino-6-chloropyrimidin-5-yloxy)-N-(tert-butoxycarbonyl)-N-methylethylamine; 4-Amino-6-chloro-5-[2-[[(1,1-dimethylethoxy)carbonyl](methyl)amino]ethoxy]pyrimidine; BOC-Protected 4-Amino-6-chloro-5-(2-(methylamino)ethoxy)pyrimidine; tert-Butyl (2-((4-amino-6-chloropyrimidin-5-yl)oxy)ethyl)(methyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-Amino-6-Chloropyrimidin-5-Yloxy)Ethylmethylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.