Description

tert-Butyl 2,4-Dichloropyrimidine-5-carboxylate is a high-value, multi-functional pyrimidine building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals, enabling efficient molecular construction. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for functionalized pyrimidines used in organic electronic materials and ligands.
• Chemical Biology: Employed in the development of molecular probes and labeled compounds for biochemical studies.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	tert-Butyl 2,4-Dichloropyrimidine-5-carboxylate
CAS No.	1786411-92-4
Molecular Formula	C9H10Cl2N2O2
Molecular Weight	249.09 g/mol
Synonyms	2,4-Dichloro-5-(tert-butoxycarbonyl)pyrimidine; 5-((tert-Butoxy)carbonyl)-2,4-dichloropyrimidine; 2,4-Dichloropyrimidine-5-carboxylic acid tert-butyl ester; tert-Butyl 2,4-dichloro-5-pyrimidinecarboxylate; 2,4-Dichloro-5-pyrimidinecarboxylic acid 1,1-dimethylethyl ester; 2,4-Dichloro-5-(tert-butyloxycarbonyl)pyrimidine; 5-Carboxy-2,4-dichloropyrimidine tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloropyrimidine-5-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.