Description

tert-Butyl 2-(2-Amino-5-Bromopyrimidin-4-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrimidine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Kinase Inhibitor Development: Used as a core scaffold for designing and optimizing potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study specific biological pathways and targets.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the custom production of complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	tert-Butyl 2-(2-Amino-5-Bromopyrimidin-4-Yl)Piperidine-1-Carboxylate
CAS No.	1785763-43-0
Molecular Formula	C14H20BrN5O2
Molecular Weight	370.25 g/mol
Synonyms	1-Boc-2-(2-Amino-5-bromopyrimidin-4-yl)piperidine; tert-Butyl 2-(2-amino-5-bromo-4-pyrimidinyl)-1-piperidinecarboxylate; 2-(2-Amino-5-bromopyrimidin-4-yl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-(2-amino-5-bromopyrimidin-4-yl)piperidine; Boc-2-(2-Amino-5-bromopyrimidin-4-yl)piperidine; 1785763-43-0; 4-Pyrimidinecarboxylic acid, 2-amino-5-bromo-4-(1-piperidinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-(2-Amino-5-Bromopyrimidin-4-Yl)Piperidine-1-Carboxylate adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.