Description

5,5-Difluorooctahydropentalene-2-Carboxylic Acid is a high-value, fluorinated bicyclic carboxylic acid building block. This compound matters for its unique structural motif, which combines the conformational rigidity of a fused ring system with the electronic and steric properties introduced by fluorine atoms. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for use in medicinal chemistry, as a precursor for novel active ingredients, and in advanced material science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in protease inhibitor and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides, where the difluorinated pentalene core can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, leveraging its rigid, fluorinated structure to modify material properties.
• Medicinal Chemistry Probe: Employed in structure-activity relationship (SAR) studies to investigate the impact of fluorination and ring conformation on bioactivity.
• Chemical Biology Tool: Can be incorporated into molecular probes and ligands for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Item	Detail
Product Name	5,5-Difluorooctahydropentalene-2-Carboxylic Acid
CAS No.	1784979-78-7
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	5,5-Difluorooctahydro-2H-pentalene-2-carboxylic acid; 2-Carboxy-5,5-difluorooctahydropentalene; Octahydro-5,5-difluoropentalene-2-carboxylic acid; 5,5-Difluoroperhydropentalene-2-carboxylic acid; 5,5-Difluorodecahydropentalene-2-carboxylic acid (related); Bicyclo[3.3.0]octane-2-carboxylic acid, 5,5-difluoro-; 1784979-78-7
EINECS	Contact for details

Quality Control

Every batch of 5,5-Difluorooctahydropentalene-2-Carboxylic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its carboxylic acid nature and sensitivity to strong bases/fluoride conditions, keep away from incompatible materials such as strong alkalis and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.