Description

3-(Difluoromethyl)-2-Fluoroaniline is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both difluoromethyl and fluoro substituents on the aniline ring, makes it a valuable precursor for creating compounds with tailored electronic and steric properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where fluorination is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed as a versatile reagent in academic and industrial labs for exploring new fluorination methodologies and constructing complex molecular architectures.

Basic Information

Product Name	3-(Difluoromethyl)-2-Fluoroaniline
CAS No.	1784796-42-4
Molecular Formula	C7H6F3N
Molecular Weight	161.12 g/mol
Synonyms	2-Fluoro-3-(difluoromethyl)aniline; 2-Fluoro-α,α-difluoro-m-toluidine; 3-(Difluoromethyl)-2-fluorobenzenamine; Benzenamine, 3-(difluoromethyl)-2-fluoro-; 2-Fluoro-3-difluoromethylaniline
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)-2-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.