Description

β,β-Difluoro-4-Methyl-Benzeneethanol is a fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the difluoromethyl group can enhance lipophilicity and systemic activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance and surface properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the difluoroethylbenzene moiety into more complex molecular architectures via coupling reactions.
• Material Science Research: Investigated for use in the development of novel organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	β,β-Difluoro-4-Methyl-Benzeneethanol
CAS No.	1783961-43-2
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	2,2-Difluoro-2-(4-methylphenyl)ethanol; 4-Methyl-α,α-difluorobenzeneethanol; 1-(4-Methylphenyl)-2,2-difluoroethanol; (4-Methylphenyl)difluoroethanol; p-Tolyldifluoroethanol; 2-(4-Methylphenyl)-2,2-difluoroethan-1-ol; β,β-Difluoro-p-methylphenethyl alcohol
EINECS	Contact for details

Quality Control

Our β,β-Difluoro-4-Methyl-Benzeneethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.