Description

5-Chloro-2,3-Difluorobenzaldehyde is a versatile fluorinated aromatic aldehyde building block, essential for the synthesis of complex organic molecules. Its value lies in the strategic positioning of chlorine and fluorine substituents, which allow for selective functionalization and tuning of electronic properties in target compounds. This intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro motif enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The aldehyde and halogen groups make it a suitable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	5-Chloro-2,3-Difluorobenzaldehyde
CAS No.	1783512-25-3
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	5-Chloro-2,3-difluorobenzaldehyde; 2,3-Difluoro-5-chlorobenzaldehyde; Benzaldehyde, 5-chloro-2,3-difluoro-; 1783512-25-3
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening sealed containers. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.