Description

2-(1,1-Difluoroethyl)- Benzaldehyde is a specialized fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. This compound matters for its unique difluoroethyl substituent, which can dramatically alter the electronic and steric properties of target molecules, influencing their reactivity, metabolic stability, and binding affinity. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by material scientists exploring new functional polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases where the difluoroethyl group is used as a bioisostere.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, improving the performance and durability of display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and altered refractive indices.
• Organic Synthesis Building Block: Utilized in various name reactions (e.g., Suzuki coupling, reductive amination) to introduce a benzaldehyde moiety with a fluorinated side chain for further functionalization.
• Fluorine-18 Radiochemistry Precursor: Potential use as a precursor or labeling synthon in the development of Positron Emission Tomography (PET) tracers for diagnostic imaging.

Basic Information

Product Name	2-(1,1-Difluoroethyl)- Benzaldehyde
CAS No.	1782543-66-1
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	2-(1,1-Difluoroethyl)benzaldehyde; 1-[2-(1,1-Difluoroethyl)phenyl]methanone; α,α-Difluoroethylbenzene-2-carboxaldehyde; Benzaldehyde, 2-(1,1-difluoroethyl)-; 2-(Difluoroethyl)benzaldehyde; o-(1,1-Difluoroethyl)benzaldehyde; 2-(1,1-Difluoroethyl)benzenecarbaldehyde
EINECS	Contact for details

Quality Control

Our 2-(1,1-Difluoroethyl)- Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, minimize headspace and exposure to air after opening. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.