Description

5-Bromo-2-Methyl-4-Trifluoromethyl-Pyrimidine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of small-molecule drugs, particularly for kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the pyrimidine core.
• Material Science Research: Serves as a precursor for organic electronic materials and liquid crystals due to its halogenated and fluorinated structure.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form C-C bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Bromo-2-Methyl-4-Trifluoromethyl-Pyrimidine
CAS No.	1781830-29-2
Molecular Formula	C6H4BrF3N2
Molecular Weight	241.01 g/mol
Synonyms	5-Bromo-2-methyl-4-(trifluoromethyl)pyrimidine; 2-Methyl-5-bromo-4-trifluoromethylpyrimidine; 4-Trifluoromethyl-5-bromo-2-methylpyrimidine; 1781830-29-2; 5-Bromo-2-methyl-4-trifluoromethyl-pyrimidine; Pyrimidine, 5-bromo-2-methyl-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methyl-4-Trifluoromethyl-Pyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.