Description

2,3-Difluoro-4-Nitroaniline is a high-purity aromatic amine derivative characterized by its strategically positioned fluorine and nitro substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in the synthesis of complex organic molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Dye and Pigment Manufacturing: Acts as a building block for creating specialized azo dyes and colorants with unique properties.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Serves as a valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex aromatic amines.
• Chemical Research & Development: A versatile reagent for exploring novel fluorination and functionalization pathways in academic and industrial R&D labs.

Basic Information

Product Name	2,3-Difluoro-4-Nitroaniline
CAS No.	1781140-23-5
Molecular Formula	C6H4F2N2O2
Molecular Weight	174.11 g/mol
Synonyms	4-Nitro-2,3-difluoroaniline; 2,3-Difluoro-4-nitrobenzenamine; 2,3-Difluoro-4-nitro-phenylamine; 1-Amino-2,3-difluoro-4-nitrobenzene; 2,3-DFNA; Aniline, 2,3-difluoro-4-nitro-; Benzenamine, 2,3-difluoro-4-nitro-
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Nitroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.