Description

1,1-Difluoro-2,3-Dihydro-1H-Inden-4-Amine is a high-value, fluorinated indane derivative serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring a difluoromethylene group and a primary amine, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its rigid indane core and functional handles.
• Chemical Biology Probe Development: Serves as a scaffold for designing molecular probes and inhibitors to study enzyme function and biological pathways.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring new methodologies in fluorination and the construction of fluorinated heterocycles.

Basic Information

Product Name	1,1-Difluoro-2,3-Dihydro-1H-Inden-4-Amine
CAS No.	1780559-04-7
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	4-Amino-1,1-difluoro-2,3-dihydro-1H-indene; 1,1-Difluoro-2,3-dihydro-1H-inden-4-amine; 1H-Inden-4-amine, 1,1-difluoro-2,3-dihydro-; 4-Amino-1,1-difluoroindane; 1,1-Difluoroindan-4-amine
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-2,3-Dihydro-1H-Inden-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.