Description

4-(Piperidin-3-Yloxy)-6-(Trifluoromethyl)Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1779128-43-6. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule therapeutics, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: Serves as a core scaffold for constructing complex molecules in preclinical and process chemistry.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Biochemical Research: Employed as a tool compound for probing biological pathways and target validation.

Basic Information

Product Name	4-(Piperidin-3-Yloxy)-6-(Trifluoromethyl)Pyrimidine Hydrochloride
CAS No.	1779128-43-6
Molecular Formula	C10H13F3N3O•HCl
Molecular Weight	283.69 g/mol (Free base)
Synonyms	6-(Trifluoromethyl)-4-(3-piperidinyloxy)pyrimidine hydrochloride; 4-(3-Piperidyloxy)-6-(trifluoromethyl)pyrimidine HCl; 4-(Piperidin-3-yloxy)-6-(trifluoromethyl)pyrimidine HCl; 1779128-43-6; 4-(3-Piperidinoloxy)-6-trifluoromethylpyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Piperidin-3-Yloxy)-6-(Trifluoromethyl)Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.