Description

Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,cis- is a high-purity, fluorinated cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its unique cis-configuration and trifluoromethoxy substituent make it a valuable scaffold for introducing conformational rigidity and lipophilicity into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its specific stereochemistry and fluorine content are essential for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the trifluoromethoxy group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and performance.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance and specific optical properties.
• Catalyst & Ligand Development: Utilized in the design of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology & Proteomics: Acts as a versatile probe or linker molecule in bioconjugation and the study of protein-ligand interactions.

Basic Information

Item	Detail
Product Name	Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,cis-
CAS No.	1773508-16-9
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	cis-3-(Trifluoromethoxy)cyclobutanecarboxylic Acid; (1s,3s)-3-(Trifluoromethoxy)cyclobutanecarboxylic Acid; rel-(1R,3R)-3-[(Trifluoromethyl)oxy]cyclobutanecarboxylic Acid; 3-(Trifluoromethoxy)cyclobutanecarboxylic Acid (cis-); cis-3-(Trifluoromethoxy)-1-cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,cis- adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure high chemical and isomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.