Description

1-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid is a high-value, fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group on a strained cyclobutane ring, makes it a versatile intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel small-molecule drugs, particularly protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved environmental profiles.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals where the cyclobutane and fluorine moieties impart specific physical properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to explore fluorination effects on potency and pharmacokinetics.
• Chemical Biology: Useful as a probe or labeling agent due to the distinct properties of the difluoromethyl group.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	1-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1773507-91-7
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	1-(Difluoromethyl)cyclobutane-1-carboxylic acid; Cyclobutane-1-carboxylic acid, 1-(difluoromethyl)-; 1-(Difluoromethyl)cyclobutane carboxylic acid; 1-Difluoromethyl-cyclobutane-1-carboxylic acid; 1773507-91-7; DFM-Cyclobutane-Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 1-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.