Description

4-Methoxy-2-(Piperidin-4-Yloxy)Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1713162-80-1. This compound is a critical building block in modern medicinal chemistry, valued for its specific pyrimidine-piperidine hybrid structure that enables targeted molecular interactions. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Kinase Inhibitor Development: Used in research and development of small molecule kinase inhibitors, a major class of targeted cancer therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Preclinical Drug Candidate Synthesis: Employed in the gram to kilogram-scale production of candidate molecules for preclinical testing and formulation studies.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP-compliant production of clinical trial materials.

Basic Information

Product Name	4-Methoxy-2-(Piperidin-4-Yloxy)Pyrimidine Hydrochloride
CAS No.	1713162-80-1
Molecular Formula	C10H15N3O2·HCl
Molecular Weight	245.71 g/mol (Free base: 209.25 g/mol)
Synonyms	4-Methoxy-2-(4-piperidinyloxy)pyrimidine hydrochloride; 2-(Piperidin-4-yloxy)-4-methoxypyrimidine HCl; 4-Methoxy-2-(piperidin-4-yloxy)pyrimidine HCl salt; UNII-8H5VKL9J7F; 1713162-80-1; 4-Methoxy-2-(4-piperidyloxy)pyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-(Piperidin-4-Yloxy)Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.