Description

5-Pyrimidinecarboxylic Acid, 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]Amino]-2-[(2S)-2-(Methoxycarbonyl)-1-Pyrrolidinyl]-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical chiral building block with a defined stereochemistry, essential for developing targeted therapeutics with high biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries working on novel drug candidates, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel small-molecule drug candidates.
• Oncology Research: Building block for the development of targeted kinase inhibitors and other anti-cancer agents.
• CNS Drug Discovery: Used in research programs focused on neurological disorders and psychiatric conditions.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process optimization and pilot-scale manufacturing of APIs.
• Custom Synthesis: Starting material for the contract manufacturing of specialized, non-commercial compounds for clinical trials.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry studies and methodology development.

Basic Information

Product Name	5-Pyrimidinecarboxylic Acid, 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]Amino]-2-[(2S)-2-(Methoxycarbonyl)-1-Pyrrolidinyl]-, Ethyl Ester
CAS No.	1711677-06-3
Molecular Formula	C21H25ClN4O5
Molecular Weight	448.90 g/mol
Synonyms	Ethyl 4-(((3-chloro-4-methoxyphenyl)methyl)amino)-2-((S)-2-(methoxycarbonyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate; (S)-Ethyl 4-(((3-chloro-4-methoxyphenyl)methyl)amino)-2-(2-(methoxycarbonyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate; UNII-8V4U3F1K4H; 8V4U3F1K4H; BDBM50389357; AKOS025147064; ZINC000253914587; A1-00849
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxylic Acid, 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]Amino]-2-[(2S)-2-(Methoxycarbonyl)-1-Pyrrolidinyl]-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.