Description

6-(Difluoromethyl)Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethyl-substituted pyrimidine core. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral, anticancer, and agrochemical products, where precise molecular modification is essential. Our supply ensures consistent quality and reliable availability for your most demanding synthesis workflows.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drugs, particularly in antiviral and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced fungicides and herbicides, leveraging the biological activity of the fluorinated pyrimidine structure.
• Chemical Research & Development: Serves as a versatile scaffold for exploring structure-activity relationships (SAR) in medicinal and agricultural chemistry programs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the final synthetic steps for producing target APIs requiring the 6-(difluoromethyl)pyrimidin-4-amine moiety.
• Ligand and Probe Development: Utilized in biochemical research for creating specialized molecular probes and enzyme inhibitors.

Basic Information

Product Name	6-(Difluoromethyl)Pyrimidin-4-Amine
CAS No.	1706464-15-4
Molecular Formula	C5H5F2N3
Molecular Weight	145.11 g/mol
Synonyms	4-Amino-6-(difluoromethyl)pyrimidine; 6-(Difluoromethyl)-4-pyrimidinamine; 4-Pyrimidinamine, 6-(difluoromethyl)-; 1706464-15-4; 6-Difluoromethylpyrimidin-4-ylamine; 6-(Difluoromethyl)-4-aminopyrimidine; Difluoromethylpyrimidinamine
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Pyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.