Description

(R)-3-(4-Phenoxyphenyl)-1-(Piperidin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Dihydrochloride is a high-purity, small molecule chemical building block of significant interest in advanced pharmaceutical research. This compound serves as a critical intermediate or reference standard in the development of targeted kinase inhibitors and other therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, immunology, and metabolic disease drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe compound in enzymatic assays and target validation studies.
• Drug Discovery & Development: Serves as a core scaffold for structure-activity relationship (SAR) optimization in medicinal chemistry programs.
• Preclinical Studies: Utilized in in vitro and in vivo studies to evaluate pharmacokinetic and pharmacodynamic properties of drug candidates.
• Chemical Biology: Employed as a tool compound to investigate specific biological pathways and protein functions.
• GMP Manufacturing: Supplied as a starting material or intermediate for the cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(R)-3-(4-Phenoxyphenyl)-1-(Piperidin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Dihydrochloride
CAS No.	1701403-10-2
Molecular Formula	C22H23N7O · 2HCl
Molecular Weight	498.39 g/mol (free base: 401.47 g/mol)
Synonyms	(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride; (R)-3-(4-Phenoxyphenyl)-1-(3-piperidyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride; 1701403-10-2; UNII-9J8C9V5U4H; 9J8C9V5U4H; CS-0886; BDBM50164953; AKOS025147064; (R)-PF-06447475 dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(4-Phenoxyphenyl)-1-(Piperidin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.