Description

1-[9H-Fluoren-9-Ylmethoxycarbonyl(Methyl)Amino]Cyclobutane-1-Carboxylic Acid is a specialized Fmoc-protected amino acid derivative featuring a cyclobutane ring. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, non-natural amino acid structures. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating the constrained 1-aminocyclobutane-1-carboxylic acid (Acbc) scaffold into peptide chains.
• Peptidomimetic Drug Discovery: Used to create conformationally restricted peptide analogs with enhanced metabolic stability, potency, and selectivity for target proteins.
• Protease Inhibitor Development: Serves as a core building block in the research and synthesis of inhibitors for various proteolytic enzymes.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: Supplied to CROs and CDMOs for the production of bespoke peptides for clients in academia and the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Item	Detail
Product Name	1-[9H-Fluoren-9-Ylmethoxycarbonyl(Methyl)Amino]Cyclobutane-1-Carboxylic Acid
CAS No.	1700368-07-5
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-1-Amino-1-cyclobutanecarboxylic acid, N-Methyl derivative; Fmoc-Acbc(Me)-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]cyclobutane-1-carboxylic acid; N-Methyl-Fmoc-1-aminocyclobutane-1-carboxylic acid; Fmoc-N-methyl-1-amino-1-cyclobutanecarboxylic acid; (1-(((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)cyclobutane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[9H-Fluoren-9-Ylmethoxycarbonyl(Methyl)Amino]Cyclobutane-1-Carboxylic Acid adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.