Description

Acetyl-Tau Peptide (273-284) Amide is a chemically synthesized peptide fragment derived from the human tau protein, a key protein of interest in neurological research. This specific acetylated and amidated sequence is critical for studying post-translational modifications and their role in protein function and aggregation. It is an essential biochemical tool for researchers and developers in the fields of neuroscience, proteomics, and therapeutic discovery. The compound is supplied as a high-purity, lyophilized powder to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: Used as a key antigen for antibody production and validation, specifically targeting modified tau protein epitopes.
• Biomarker Development: Serves as a reference standard in immunoassays (ELISA, Western Blot) for the detection and quantification of pathological tau species.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) assays to identify potential inhibitors of tau aggregation or modulators of tau phosphorylation.
• Structural Biology Studies: Utilized in biophysical studies, such as NMR spectroscopy or X-ray crystallography, to investigate tau protein structure and interaction dynamics.
• Diagnostic Kit Manufacturing: Incorporated as a calibrated component in diagnostic kits for neurodegenerative diseases like Alzheimer's.
• Academic & Pharmaceutical R&D: Provides a well-defined, high-quality reagent for basic research and preclinical development of tau-targeted therapies.

Basic Information

Product Name	Acetyl-Tau Peptide (273-284) Amide
CAS No.	1684399-52-7
Molecular Formula	C70H112N20O22
Molecular Weight	1553.8 g/mol
Synonyms	Ac-Tau (273-284)-NH2; Acetylated Tau Peptide 273-284 amide; N-Acetyl-Tau (273-284) amide; Ac-HQGGGKVQIINKK-NH2; Tau protein (273-284) (acetylated) amide; Modified tau peptide fragment; Ac-HQGGGKVQIINKK-NH2; Research-grade tau peptide
EINECS	Contact for details

Quality Control

Every batch of Acetyl-Tau Peptide (273-284) Amide is manufactured under strict quality management systems. Purity is rigorously verified by analytical HPLC (≥95%) and mass spectrometry (MS) for identity confirmation. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0% (by weight)
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ±10% of theoretical
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.