Description

Amyloid β-Protein (2-42) CAS NO 1678416-22-2 is a specific peptide fragment of the amyloid precursor protein (APP), a key molecule in Alzheimer's disease research. This peptide is crucial for studying the aggregation mechanisms and neurotoxic effects associated with β-amyloid plaque formation. It is an essential biochemical tool for researchers and pharmaceutical developers in the fields of neuroscience, drug discovery, and diagnostic assay development.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid-beta peptides in Alzheimer's disease pathology.
• Drug Discovery & Screening: Used as a target or reference standard in high-throughput screening (HTS) assays to identify potential therapeutic compounds that inhibit aggregation or promote clearance.
• Diagnostic Development: Serves as a critical antigen or standard in the development and validation of immunoassays (ELISA, Western Blot) for detecting amyloid-beta species in biological samples.
• Biophysical Studies: Employed in techniques like surface plasmon resonance (SPR), nuclear magnetic resonance (NMR), and electron microscopy to characterize peptide-protein interactions and fibril formation.
• Antibody Production & Validation: Acts as an immunogen for generating specific antibodies or as a control for testing antibody specificity against various Aβ fragments.
• Cell Culture & In Vitro Models: Used to treat neuronal cell cultures to model amyloid-induced cytotoxicity and study cellular pathways involved in neurodegeneration.

Basic Information

Product Name	Amyloid β-Protein (2-42)
CAS No.	1678416-22-2
Molecular Formula	C194H295N55O58S
Molecular Weight	4334.8 g/mol
Synonyms	Aβ (2-42); Amyloid β-Protein (2-42); Amyloid β-Peptide (2-42); β-Amyloid Peptide (2-42); Aβ1-42 (2-42 fragment); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (2-42) is produced and analyzed under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques, with purity typically exceeding 95% as determined by HPLC. Our quality commitment includes identity confirmation by mass spectrometry (MS) and peptide content analysis. Certificates of Analysis (COA) detailing purity, sequence verification, and endotoxin levels are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers (e.g., DMSO, NH4OH) and stored as single-use aliquots at ≤ -70°C to prevent repeated freeze-thaw cycles and degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Solubility	Soluble in DMSO or dilute basic solutions (e.g., 0.1% NH4OH)
Endotoxin Level	< 1.0 EU/mg
Sequence	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.