Description

Amyloid β-Protein (5-42) is a specific peptide fragment derived from the larger amyloid precursor protein, representing a key sequence involved in β-sheet formation. This compound is of significant interest for its role in the study of amyloid fibril aggregation mechanisms and neurotoxicity. It is primarily utilized by researchers and pharmaceutical developers in neuroscience, biochemistry, and drug discovery for investigating Alzheimer's disease pathology and screening potential therapeutic agents.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structural properties, and toxicity of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate inhibitors of amyloid fibril formation.
• Antibody & Diagnostic Development: Serves as a critical antigen for the production and characterization of antibodies used in diagnostic kits and imaging probes.
• In Vitro Model Systems: Employed to create synthetic amyloid plaques in cell culture and other model systems to study disease mechanisms.
• Biophysical Characterization: Analysis of peptide secondary structure, stability, and oligomerization using techniques like circular dichroism (CD) and nuclear magnetic resonance (NMR).
• Reference Standard: Acts as a purified, well-characterized standard for quantitative analysis in mass spectrometry and chromatography.

Basic Information

Product Name	Amyloid β-Protein (5-42)
CAS No.	1678415-97-8
Molecular Formula	C185H277N51O57S
Molecular Weight	4083.6 g/mol
Synonyms	Amyloid β-Protein (5-42); Aβ(5-42); Amyloid β-Peptide (5-42); β-Amyloid Peptide (5-42); Aβ5-42; Amyloid-β (5-42); APP(672-713); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (5-42) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4083.6 ± 2.0 Da (by MS)
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.