Description

Amyloid β-Protein (1-40) (Scrambled) is a synthetic peptide variant of the amyloid beta protein, where the amino acid sequence has been deliberately randomized. This product is a critical research-grade biochemical tool, specifically designed to serve as a negative control in Alzheimer's disease and amyloidosis studies. It is essential for scientists and pharmaceutical developers in neuroscience, biochemistry, and drug discovery who require high-purity, well-characterized peptides to validate experimental results and ensure data accuracy.

Application

• Negative Control in Alzheimer's Research: Used as a critical control peptide in assays studying the aggregation, toxicity, and cellular mechanisms of native amyloid-beta (1-40).
• Biophysical Studies: Employed in comparative studies using techniques like circular dichroism (CD), nuclear magnetic resonance (NMR), and surface plasmon resonance (SPR) to understand sequence-specific folding and interaction properties.
• Antibody Specificity Testing: Essential for validating the specificity of antibodies raised against the native amyloid-beta sequence in ELISA, Western blot, and immunohistochemistry applications.
• Drug Discovery Screening: Serves as a control compound in high-throughput screening (HTS) campaigns to identify inhibitors of amyloid-beta aggregation, helping to rule out non-specific effects.
• Teaching and Method Development: A valuable reagent for academic laboratories for training purposes and for developing new analytical methods in peptide science.

Basic Information

Product Name	Amyloid β-Protein (1-40) (Scrambled)
CAS No.	1678415-68-3
Molecular Formula	C194H295N55O58S
Molecular Weight	4329.8 g/mol
Synonyms	Aβ (1-40) scrambled; Amyloid β-Protein (1-40) scrambled control; Scrambled Amyloid-β (1-40); Aβ1-40 scrambled peptide; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (scrambled); Scrambled Abeta40; Control peptide for Alzheimer's research; Random sequence Aβ40.
EINECS	Contact for details

Quality Control

Every batch of our Amyloid β-Protein (1-40) (Scrambled) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data including HPLC purity (typically >95%), mass spectrometry (MS) for sequence confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all quality parameters for your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by AAA)
Solubility	Soluble in water or dilute aqueous acetic acid
Single Impurity (HPLC)	≤ 1.0%
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.