Description

Amyloid β-Protein (1-42) (Scrambled) Trifluoroacetate Salt is a synthetic peptide variant of the amyloid-beta protein, where the amino acid sequence has been intentionally randomized. This compound is a critical research-grade biochemical tool, primarily utilized as a negative control in Alzheimer's disease and amyloidosis studies to validate the specific biological effects of the native-sequence Aβ(1-42). It is essential for pharmaceutical R&D, academic research, and diagnostic development laboratories focused on neurodegenerative disease mechanisms, protein aggregation, and therapeutic screening.

Application

• Negative Control in Alzheimer's Research: Serves as a crucial control to distinguish sequence-specific aggregation and toxicity from non-specific effects in cellular and biochemical assays.
• Assay Validation & Development: Used to validate the specificity of ELISA kits, Western blot antibodies, and other detection methods targeting the native Aβ(1-42) sequence.
• Protein Aggregation Studies: Employed in comparative studies to understand the kinetics and thermodynamics of amyloid fibril formation relative to the scrambled sequence.
• Drug Discovery Screening: Acts as a control compound in high-throughput screens designed to identify inhibitors of Aβ(1-42) aggregation or toxicity.
• Teaching & Methodological Standard: Provides a reference material in academic settings for teaching principles of peptide chemistry, protein misfolding, and experimental design.
• Quality Control for Peptide Synthesis: Used as a process control to benchmark synthesis and purification protocols for complex, aggregation-prone peptides.

Basic Information

Product Name	Amyloid β-Protein (1-42) (Scrambled) Trifluoroacetate Salt
CAS No.	1678415-52-5
Molecular Formula	C203H311N55O60S • xC2HF3O2
Molecular Weight	~4514.0 g/mol (free base)
Synonyms	Aβ(1-42) Scrambled; Scrambled Amyloid-β (1-42); Amyloid β-Protein (1-42) Scrambled Control; Scrambled Aβ42; Aβ42 Scrambled Peptide; Amyloid β-Peptide (1-42) Scrambled; Random Sequence Aβ(1-42); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Scrambled)
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under stringent quality systems. Each batch of Amyloid β-Protein (1-42) (Scrambled) Trifluoroacetate Salt undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We support compliance with relevant research guidelines, and custom purity grades or specific quality attributes can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular weight
Purity (HPLC)	≥95%
Peptide Content	≥70% (by weight)
Amino Acid Analysis	Composition agrees with theoretical values
Solubility	Soluble in water or dilute aqueous acetic acid
Endotoxin Level	<1.0 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.