Description

C(Npys)Rrrrrrrrr-Nh2 CAS NO 1676104-79-2 is a specialized chemical building block featuring a reactive amine group and a nitropyridinesulfonyl (Npys) protecting group. This compound is critical for advanced organic synthesis, particularly in peptide chemistry and bioconjugation, where it enables controlled, site-specific modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and complex biomolecules.

Application

• Peptide Synthesis: Serves as a key intermediate for the introduction of protected amine functionalities during solid-phase and solution-phase peptide assembly.
• Bioconjugation & Linker Chemistry: Used to create cleavable linkers for antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Protecting Group Strategy: The Npys group allows for selective deprotection under mild conditions, facilitating complex multi-step synthetic routes.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Material Science Functionalization: Applied to modify surfaces and polymers with reactive amine handles for creating advanced functional materials.
• Pharmaceutical Intermediate: Acts as a precursor in the synthesis of active pharmaceutical ingredients (APIs) with specific targeting moieties.

Basic Information

Product Name	C(Npys)Rrrrrrrrr-Nh2
CAS No.	1676104-79-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-(2-Nitropyridinesulfonyl)-protected amine derivative; Npys-protected alkylamine; 2-Nitrobenzenesulfonamide derivative; Chemical Building Block 1676104-79-2; Amino-Npys reagent; Nitropyridinesulfonyl amine intermediate; Protected synthetic intermediate
EINECS	Contact for details

Quality Control

Our C(Npys)Rrrrrrrrr-Nh2 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.