Description

Fmoc-Thr(Tbu)-Thr(Psi(Me,Me)Pro)-Oh is a specialized, high-purity pseudoproline dipeptide building block designed for solid-phase peptide synthesis (SPPS). This compound is engineered to address the critical challenge of difficult sequences and aggregation during peptide chain assembly, thereby enhancing synthesis efficiency and yield. It is an essential raw material for research institutions and pharmaceutical companies developing therapeutic peptides, peptidomimetics, and complex biomolecules. The CAS number for this compound is 1676104-73-6.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing pseudoproline motifs to prevent aggregation and improve the synthesis of challenging sequences.
• Pharmaceutical R&D: For the discovery and development of novel therapeutic peptides and peptidomimetic drugs targeting various diseases.
• Peptide Library Construction: Used in combinatorial chemistry to create diverse libraries for high-throughput screening and drug discovery.
• Bioconjugation & Protein Engineering: As a modified amino acid for introducing specific structural constraints or functional handles into engineered proteins.
• Academic Research: In university and institutional labs studying peptide structure, folding, and function.
• Process Development: For scaling up the production of peptide-based active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	Fmoc-Thr(Tbu)-Thr(Psi(Me,Me)Pro)-Oh
CAS No.	1676104-73-6
Molecular Formula	C33H51N3O8
Molecular Weight	617.78 g/mol
Synonyms	Fmoc-Thr(tBu)-Thr[ψ(Me,Mepro)]-OH; Fmoc-Thr(tBu)-Thr(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-threonyl-L-threonyl-N,2-dimethyl-L-proline; Fmoc-L-Thr(tBu)-L-Thr(ψMe,MePro)-OH; Pseudoproline Dipeptide Derivative; Fmoc-protected Pseudoproline; SPPS Building Block
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Tbu)-Thr(Psi(Me,Me)Pro)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for critical research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development toward cGMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.