Description

(Thr(Poh)231)-Tau Peptide (225-237) CAS NO 1670270-09-3 is a chemically synthesized, phosphorylated peptide fragment corresponding to residues 225-237 of the human tau protein, with a specific phosphorylation modification at the threonine 231 position. This peptide is a critical research tool for studying the molecular mechanisms of tauopathies, including Alzheimer's disease, as phosphorylation at this site is a key pathological event. It is primarily utilized by researchers and pharmaceutical developers in neuroscience, biochemistry, and drug discovery for use as an antigen, standard, or biochemical probe.

Application

• Biomedical Research: Used as a key antigen for developing and characterizing antibodies specific to phosphorylated tau protein.
• Diagnostic Development: Serves as a critical standard or calibrator in immunoassays (e.g., ELISA) designed to detect pathological tau in biological samples.
• Drug Discovery & Screening: Employed in high-throughput screening assays to identify and validate compounds that modulate tau phosphorylation or aggregation.
• Mechanistic Studies: Essential for in vitro studies investigating kinase and phosphatase activity related to tau pathology.
• Biomarker Validation: Used to validate the specificity and sensitivity of novel detection platforms for neurodegenerative disease biomarkers.
• Academic & Institutional Research: Fundamental reagent for university and research institute labs focused on neurodegeneration and cell signaling pathways.

Basic Information

Product Name	(Thr(Poh)231)-Tau Peptide (225-237)
CAS No.	1670270-09-3
Molecular Formula	C65H106N20O23P
Molecular Weight	1543.6 g/mol (monoisotopic)
Synonyms	Tau (225-237) Phospho (Thr231) Peptide; pT231 Tau Peptide; Phosphorylated Tau Protein Fragment (225-237); Human Tau Phosphopeptide (pT231); Microtubule-Associated Protein Tau Phosphopeptide; Tau-pThr231 (225-237); pThr231-Tau (225-237); Synthetic Phospho-Tau Peptide
EINECS	Contact for details

Quality Control

Every batch of (Thr(Poh)231)-Tau Peptide (225-237) is produced and analyzed under strict quality protocols to ensure identity, purity, and batch-to-batch consistency for research reproducibility. Our quality assurance includes comprehensive analytical characterization using HPLC, MS (Mass Spectrometry), and amino acid analysis. A detailed Certificate of Analysis (COA) providing purity, molecular weight confirmation, and solubility data is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	1543.6 ± 1.0 Da
Amino Acid Composition	Conforms to theoretical sequence
Solubility	Soluble in water or aqueous buffers
Single Spot on TLC	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.