Description

Fmoc-L-Lys(Boc-Aeea)-Oh is a specialized, high-purity protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise, multi-step assembly of complex peptides and peptidomimetics, particularly for drug discovery and bioconjugation applications. It is essential for the synthesis of peptide-drug conjugates (PDCs), antibody-drug conjugates (ADCs), and other therapeutic biomolecules where controlled linker integration is paramount. This product serves the needs of pharmaceutical R&D, biotechnology, and fine chemical synthesis sectors globally.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of peptides.
• Peptide-Drug Conjugate (PDC) Development: Incorporation of the Aeea (aminoethoxyethoxyacetyl) linker for creating stable, cleavable connections between peptide carriers and cytotoxic payloads.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used in the synthesis of sophisticated linker-payload constructs for targeted cancer therapies.
• Synthesis of Branched or Multi-functional Peptides: Utilizes the orthogonal protection (Fmoc, Boc) on the lysine side chain for introducing additional functional groups or branching points.
• Bioconjugation and Labeling: Serves as a precursor for attaching fluorescent dyes, biotin, or other probes to peptides and proteins via the free carboxyl group after deprotection.
• Research & Development of Novel Therapeutics: Fundamental material for academic and industrial research in oncology, diagnostics, and targeted delivery systems.

Basic Information

Item	Details
Product Name	Fmoc-L-Lys(Boc-Aeea)-Oh
CAS No.	1662688-16-5
Molecular Formula	C₃₃H₄₅N₃O₉
Molecular Weight	627.73 g/mol
Synonyms	Fmoc-Lys(Boc-AEEA)-OH; Nα-Fmoc-Nε-[(tert-butoxycarbonyl)aminoethoxyethoxyacetyl]-L-lysine; Fmoc-Lys(Boc-aminoethoxyethoxyacetyl)-OH; Fmoc-Lys(Boc-Aeea)-OH; (2S)-6-[[2-[2-(tert-Butoxycarbonylamino)ethoxy]ethoxy]acetyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-Lys(Boc-AEEA)-OH CAS 1662688-16-5; AEEA-linked Fmoc-Lys(Boc)-OH; Boc-AEEA-Fmoc-Lys-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-Lys(Boc-Aeea)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. Our quality commitment aligns with the standards required for GMP starting materials and pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.