Description

Pyrimido[5,4-B]Indolizine-4,8-Diamine, 8,9-Dihydro-6-Methyl-5-(3-Quinolinyl)-, (8S)- is a complex, chiral heterocyclic compound with a fused pyrimidoindolizine-quinoline scaffold, representing a sophisticated building block for advanced research. This compound matters as a high-value pharmaceutical intermediate or biological probe, enabling the development of novel therapeutic agents and the study of specific biological pathways. It is primarily needed by researchers and developers in medicinal chemistry, pharmaceutical R&D, and academic institutions focused on drug discovery for challenging disease targets.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel small-molecule drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Kinase Inhibitor Development: The fused heterocyclic structure is suitable for designing potential inhibitors of specific kinase enzymes involved in cancer and inflammatory disorders.
• Chemical Biology Probe: Serves as a tool compound to investigate and modulate specific biological targets and pathways in cellular assays.
• High-Throughput Screening (HTS): Included in specialized compound libraries for screening against novel biological targets to identify hit molecules.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in universities and research institutes for synthetic methodology development and exploring new chemical space.

Basic Information

Product Name	Pyrimido[5,4-B]Indolizine-4,8-Diamine, 8,9-Dihydro-6-Methyl-5-(3-Quinolinyl)-, (8S)-
CAS No.	1661855-22-6
Molecular Formula	C22H20N6
Molecular Weight	368.44 g/mol
Synonyms	(8S)-8,9-Dihydro-6-methyl-5-(quinolin-3-yl)pyrimido[5,4-b]indolizine-4,8-diamine; (8S)-5-(3-Quinolinyl)-8,9-dihydro-6-methyl-pyrimido[5,4-b]indolizine-4,8-diamine; 1661855-22-6; UNII-9K7J3V6W8P; 9K7J3V6W8P; Pyrimido[5,4-b]indolizine-4,8-diamine, 8,9-dihydro-6-methyl-5-(3-quinolinyl)-, (8S)-; SCHEMBL21804219
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support research and development needs. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and GMP for non-clinical materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.