Description

Fmoc-Phe-Cit-Pab CAS NO 1656305-20-2 is a specialized, high-purity synthetic peptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers developing complex peptide-based pharmaceuticals and biochemical tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, targeted drug delivery, and protease inhibitor development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected intermediate for the controlled assembly of custom peptide sequences.
• Pharmaceutical Research: In the development of novel peptide-drug conjugates (PDCs) and targeted therapeutics, particularly those requiring a para-aminobenzyloxycarbonyl (Pab) linker for drug release.
• Protease-Sensitive Linker Integration: The Citrulline (Cit) residue is often employed to create substrates cleavable by specific proteases like cathepsin B, enabling tumor microenvironment-responsive drug activation.
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as a crucial component in constructing the linker-payload complex for next-generation ADCs.
• Biochemical Probe Development: For creating labeled peptides used in enzyme activity assays and molecular imaging studies.
• Process Development & Scale-Up: Used in process chemistry for optimizing the manufacturing routes of therapeutic peptides.

Basic Information

Product Name	Fmoc-Phe-Cit-Pab
CAS No.	1656305-20-2
Molecular Formula	C41H44N6O8
Molecular Weight	748.83 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N5-[(diaminomethylene)amino]-N-[(4-aminophenyl)methoxy]carbonyl]-L-ornithine; Fmoc-Phenylalanyl-citrullyl-p-aminobenzyl alcohol; Fmoc-L-Phe-L-Cit-PAB; Fmoc-Phe-Cit-PAB-OH; (9-Fluorenylmethyloxycarbonyl)-Phenylalanyl-Citrullyl-para-Aminobenzyl Alcohol; Fmoc-Phe-Cit-PAB linker; ADC Linker Fmoc-Phe-Cit-PAB
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Phe-Cit-Pab is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are produced to meet the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.