Description

tert-Butyl4-Bromo-3,5-Dimethyl-2,6-Dioxo-3,6-Dihydropyrimidine-1(2H)-Carboxylate is a high-purity, protected pyrimidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic combination of a reactive bromine substituent and a tert-butyloxycarbonyl (Boc) protecting group, enabling precise, multi-step molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in constructing advanced pyrimidine-based herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a precursor for activity-based probes or affinity tags to study enzyme function and protein interactions.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry within R&D laboratories.
• Custom Synthesis: Employed by fine chemical manufacturers for the bespoke production of complex molecules for client-specific projects.

Basic Information

Product Name	tert-Butyl4-Bromo-3,5-Dimethyl-2,6-Dioxo-3,6-Dihydropyrimidine-1(2H)-Carboxylate
CAS No.	1643462-61-6
Molecular Formula	C11H15BrN2O4
Molecular Weight	319.15 g/mol
Synonyms	1-Boc-4-bromo-3,5-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine; 4-Bromo-3,5-dimethyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-bromo-3,5-dimethyl-2,6-dioxo-1,6-dihydropyrimidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-bromo-3,5-dimethylpyrimidine-2,6(1H,3H)-dione; Boc-4-Br-3,5-dimethyluracil; 4-Bromo-3,5-dimethyl-1-Boc-uracil
EINECS	Contact for details

Quality Control

Our production of tert-Butyl4-Bromo-3,5-Dimethyl-2,6-Dioxo-3,6-Dihydropyrimidine-1(2H)-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.