Description

Fmoc-Sec(Trt)-Oh CAS NO 1639843-37-0 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound provides critical protection for the selenocysteine side chain, enabling the controlled synthesis of complex peptides and proteins containing this important amino acid. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, biochemical probes, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the site-specific incorporation of selenocysteine into synthetic peptide chains.
• Pharmaceutical Research: For the development of peptide-based drug candidates, including those with enhanced stability or specific catalytic functions.
• Selenoprotein Mimicry: In the synthesis of peptides that model the active sites of natural selenoenzymes like glutathione peroxidase for biochemical studies.
• Bioconjugation & Probe Development: As a precursor for creating labeled peptides or affinity tags that exploit the unique reactivity of selenium.
• Chemical Biology Tool Development: For producing peptides used to study protein folding, redox regulation, and metal binding in biological systems.
• Process Development & Scale-Up: Serves as a critical raw material for contract manufacturing organizations (CMOs) scaling up peptide APIs for clinical trials.

Basic Information

Product Name	Fmoc-Sec(Trt)-Oh
CAS No.	1639843-37-0
Molecular Formula	C37H31NO4Se
Molecular Weight	624.61 g/mol
Synonyms	Fmoc-Selenocysteine(Trt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(triphenylmethyl)selanyl]-L-alanine; Fmoc-Sec(Trt)-OH; Fmoc-L-Selenocysteine(Trt)-OH; Nα-Fmoc-Nβ-Trt-L-selenocysteine; Fmoc-Sec(Mmt)-OH (common alternate protection); Fmoc-Selenocysteine (Trt protected); (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(triphenylmethylselanyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Sec(Trt)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements of peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles. We adhere to cGMP principles for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.