Description

Di-Fmoc-Seleno-L-Cystine is a specialized, high-purity protected amino acid derivative designed for advanced peptide synthesis. This compound is critically important for the controlled incorporation of selenocysteine, a key amino acid in selenoproteins, enabling research into redox biology and enzyme function. It is an essential building block for pharmaceutical researchers, biochemists, and CROs developing novel peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the Fmoc-strategy synthesis of peptides containing selenocysteine residues.
• Selenoprotein Research: Used in the study and production of model selenoproteins to investigate their catalytic mechanisms and biological roles.
• Pharmaceutical R&D: Enables the development of novel peptide drugs with enhanced stability or specific redox-active properties.
• Bioconjugation & Probe Development: Serves as a precursor for creating selenol-containing probes used in labeling and studying protein structure and interactions.
• Antioxidant Enzyme Mimics: A building block for synthesizing peptides that mimic the activity of glutathione peroxidase and other antioxidant enzymes.
• Chemical Biology Tool: Facilitates site-specific incorporation of selenium into peptides for X-ray crystallography (MAD phasing) and other structural biology techniques.

Basic Information

Product Name	Di-Fmoc-Seleno-L-Cystine
CAS No.	1639843-33-6
Molecular Formula	C40H32N2O8Se2
Molecular Weight	834.62 g/mol
Synonyms	Bis(9H-fluoren-9-ylmethyl) (2R,2'R)-diselanediylbis(3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoate); N,N'-Bis(9-fluorenylmethoxycarbonyl)-L-selenocystine; Di-Fmoc-L-selenocystine; Fmoc-Sec(Se-Se)-OH; Fmoc-Selenocystine; L-Selenocystine, N,N'-bis(9-fluorenylmethyloxycarbonyl)-; (2R,2'R)-3,3'-Diselanediylbis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid)
EINECS	Contact for details

Quality Control

Our Di-Fmoc-Seleno-L-Cystine is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.