Description

7-(Benzenesulfonyl)-2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of novel kinase inhibitors and targeted therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers seeking reliable, high-quality building blocks for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Serves as a core scaffold for the research and development of potent and selective kinase inhibitors due to its pyrrolopyrimidine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery programs.
• Bioconjugation & Probe Synthesis: The carboxylic acid functionality allows for further derivatization, making it suitable for creating chemical probes or antibody-drug conjugates (ADC) linkers.
• Academic & Industrial R&D: Employed in university and corporate research settings for exploring new chemical entities and biological pathways.

Basic Information

Product Name	7-(Benzenesulfonyl)-2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylic Acid
CAS No.	1638768-44-1
Molecular Formula	C₁₃H₇Cl₂N₃O₄S
Molecular Weight	376.18 g/mol
Synonyms	2,4-Dichloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid; 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid, 2,4-dichloro-7-(phenylsulfonyl)-; 7-(Phenylsulfonyl)-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid; Benzenesulfonyl-dichloro-pyrrolopyrimidine-carboxylic acid; CAS 1638768-44-1
EINECS	Contact for details

Quality Control

Our 7-(Benzenesulfonyl)-2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.