Description

2-Chloro-5-Fluoro-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, heterocyclic building block of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the synthesis of kinase inhibitors and other targeted therapeutics. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality raw materials for drug discovery and API manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of novel small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in the multi-step synthesis of complex API molecules for preclinical and clinical trials.
• Biochemical Tool Compound Synthesis: Employed to create specialized chemical probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects for global clients.
• Fine Chemical Production: Used in the manufacture of advanced, high-value specialty chemicals beyond pharmaceuticals.

Basic Information

Product Name	2-Chloro-5-Fluoro-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1638768-28-1
Molecular Formula	C6H3ClFN3
Molecular Weight	171.56 g/mol
Synonyms	2-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 2-chloro-5-fluoro-; 2-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine; 2-Chloro-5-fluoropyrrolo[2,3-d]pyrimidine; 5-Fluoro-2-chloro-7H-pyrrolo[2,3-d]pyrimidine; CAS 1638768-28-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.