Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(4-Piperidinyl)-2-Pyridinyl]Amino]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key building block in the synthesis of targeted kinase inhibitors. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of novel therapeutic agents for oncology and other disease areas. The CAS number for this product is 1637781-04-4.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent and selective kinase inhibitor drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Oncology Drug Development: Serves as a key building block for compounds targeting specific signaling pathways involved in cancer cell proliferation and survival.
• Biochemical Assay Development: Can be utilized as a reference standard or probe molecule in high-throughput screening (HTS) and enzymatic assays.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of bespoke molecules for client-sponsored research programs.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(4-Piperidinyl)-2-Pyridinyl]Amino]-
CAS No.	1637781-04-4
Molecular Formula	C25H31N5O2
Molecular Weight	433.55 g/mol
Synonyms	6-Acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperidin-4-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one; 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; 1637781-04-4; UNII-9K3A6S3V6S; 9K3A6S3V6S; CHEMBL3186662; BDBM50157857; AKOS025147324.
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-7(8H)-One intermediate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.