Description

Fmoc-(R)-3-Amino-4-(3-Bromo-Phenyl)-Butyric Acid CAS NO 1632296-29-7 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a brominated aromatic side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise introduction of a lipophilic, halogenated moiety. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic peptides, protein-protein interaction inhibitors, and targeted drug conjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the automated synthesis of custom peptides containing the (R)-3-amino-4-(3-bromophenyl)butyric acid residue.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drug candidates, particularly for oncology, metabolic diseases, and CNS disorders where the bromophenyl group can enhance binding affinity or modulate pharmacokinetics.
• Peptidomimetic Design: Serves as a scaffold for creating non-peptide analogs that mimic the structure and function of natural peptides, improving metabolic stability.
• Chemical Biology Probes: Incorporated into peptides used as tools to study enzyme mechanisms, protein interactions, and cellular signaling pathways, where the bromine atom can serve as a handle for further modification (e.g., cross-linking, fluorescent labeling).
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse libraries of compounds for high-throughput screening against biological targets.
• API Intermediate Manufacturing: Employed in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that require this specific chiral amino acid framework.

Basic Information

Item	Details
Product Name	Fmoc-(R)-3-Amino-4-(3-Bromo-Phenyl)-Butyric Acid
CAS No.	1632296-29-7
Molecular Formula	C25H22BrNO4
Molecular Weight	480.35 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(3-bromophenyl)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(3-bromophenyl)butyric acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-bromophenyl)butanoic acid; Fmoc-D-3-BrPhe(4)-OH (common abbreviation); Fmoc-(R)-3-Br-hPhe(4)-OH; Nα-Fmoc-3-amino-4-(3-bromophenyl)butyric acid; (R)-3-Amino-4-(3-bromophenyl)butyric acid Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(3-Bromo-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical purity, to ensure it meets the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.