Description

Fmoc-n-Me-Gln(Trt)-Oh CAS NO 1632075-13-8 is a protected amino acid derivative, specifically an N-methylated glutamine analog with Fmoc and trityl protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of modified amino acids to create peptides with enhanced stability, bioavailability, and specific biological activity. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced materials science who require high-purity, specialized intermediates for novel peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, sequential assembly of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetics Design: Facilitates the creation of peptide-like molecules with improved metabolic stability and receptor binding by incorporating N-methylated amino acids.
• Bioconjugation and Probe Development: Serves as a building block for synthesizing labeled peptides used in imaging, diagnostics, and biochemical assays.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide compounds for high-throughput screening.
• Academic and Institutional Research: Supports fundamental studies in biochemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-n-Me-Gln(Trt)-Oh
CAS No.	1632075-13-8
Molecular Formula	C41H38N2O5
Molecular Weight	638.75 g/mol
Synonyms	Fmoc-N-methyl-L-glutamine(Trt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-glutamine trityl ester; Fmoc-N-Me-Gln(Trt)-OH; Nα-Fmoc-Nα-methyl-L-glutamine Nγ-trityl; (2S)-5-[(Tritylamino)-4-oxo-2-[[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino]butanoic acid; Fmoc-N-Me-Gln(Trt)-OH CAS 1632075-13-8; Nα-Fmoc-Nα-methylglutamine γ-trityl ester
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Gln(Trt)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.