Description

4-Bromomethyl-6-Trifluoromethylpyrimidine CAS NO 1630907-33-3 is a versatile and highly functionalized pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a stable trifluoromethyl moiety, makes it invaluable for introducing key pharmacophores and modifying physicochemical properties in target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Employed in the synthesis of specialized ligands, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent handle for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Building Block: Serves as a source of the CF3 group for further functionalization in medicinal chemistry to improve metabolic stability and membrane permeability.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tags for studying biological systems.

Basic Information

Product Name	4-Bromomethyl-6-Trifluoromethylpyrimidine
CAS No.	1630907-33-3
Molecular Formula	C6H4BrF3N2
Molecular Weight	241.01 g/mol
Synonyms	6-(Trifluoromethyl)-4-pyrimidinemethanol, 4-bromo derivative; 4-(Bromomethyl)-6-(trifluoromethyl)pyrimidine; 6-Trifluoromethyl-4-bromomethylpyrimidine; 4-Bromomethyl-6-trifluoromethyl-pyrimidine; 4-Bromo-6-trifluoromethyl-pyrimidine-methanol; Pyrimidine, 4-(bromomethyl)-6-(trifluoromethyl)-; 4-Bromomethyl-6-(trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 4-Bromomethyl-6-Trifluoromethylpyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.